Primary ovarian failure or primary ovarian insufficiency is a condition in which a person’s ovaries quit functioning before they reach the age of 40.
According to research, stem cells could be employed to help people with POI improve their ovarian function.
Patients with POI have ovarian dysfunction and irregular or nonexistent menstrual periods well before menopause, often as early as their adolescence.
Ovaries contain 1-2 million eggs at birth, each encased in a sac-like structure known as a follicle.
A follicle fully matures every month, beginning at adolescence, resulting in the release of a mature egg – ovulation.
POI patients, on the other hand, have an exceptionally low number of follicles in their ovaries, and those that do exist are frequently defective and do not mature normally.
As a result, their ovaries stop generating sex hormones and releasing eggs on a regular basis, if at all, resulting in a significant reduction in fertility.
Despite the fact that ovarian activity can occur at any time, only 5-10% of persons with POI are able to conceive spontaneously.
Furthermore, unless donor eggs are used, reproductive treatments have a low success rate.
Primary Ovarian Failure Symptoms
The symptoms of primary ovarian insufficiency are similar to those of menopause or estrogen deficiency. The following are the details:
- Irregular or skipped periods, which can endure for years or appear after pregnancy or the cessation of birth control pills
- Having difficulty conceiving a child
- Heat flashes
- Night sweats
- The vaginal canal is dry.
- Eyes that are dry
- Irritability or a lack of ability to focus
- Low sexual desire
Primary Ovarian Failure: What Causes It?
Researchers are attempting to determine the cause of POI. Any disorder that causes the number of eggs in the ovaries to decrease can cause it.
It can happen even if you have a normal number of eggs if your ovaries don’t produce enough hormones.
Some of the known causes of POI are as follows:
- Autoimmune disease
- Eating Disorders
- Genetic illnesses such as Turner syndrome, Fragile X syndrome, and galactosemia exist.
- Mumps and other ovaries-damaging infections
- Follicle-stimulating hormone, for example, is a hormone that regulates the ovaries and may cause issues (FSH)
- Surgery on the ovaries
- Thyroid disease
- Toxins that injure the ovaries, such as those produced by chemotherapy or radiation
Most of the time, the reason for the problem is unknown.
How Stem Cell Therapy Can Treat Primary Ovarian Failure
As stem cells can regenerate and develop into a variety of cell types, they hold promise for treating a variety of disorders.
Stem cells may be able to restore menstruation, hormone levels, and, in rare cases, the ability to conceive, according to mounting data from preclinical and clinical trials.
These cells appear to have a positive impact on ovarian function by releasing chemicals that prevent ovarian aging, restrict ovarian cell death, and promote blood vessel development. Furthermore, stem cells exhibit antifibrotic, anti-inflammatory, and immunomodulatory properties.
Overall, the patients in this current trial who received stem cells had a better ovarian function, as seen by the increased number of follicles at various stages of development.
The favorable effect of the stem cells was highlighted by the fact that subjects who received an injection in only one of the ovaries grew follicles in that ovary but not in the other.
Visit Shifa Rejuvenation Clinic to find out about certified stem cell treatment and to locate a trustworthy stem cell therapy center in your area that provides high-quality services.
This hospital has a license from the Drug Regulatory Authority of Pakistan (DRAP), and it is regulated by the Food and Drug Administration (FDA).